The last two research studies on CFIDS highlight the OXIDATIVE STRESS AND MITROCHRONDIAL DYSFUNCTION. No Gulf War Veterans were tested in these studies from the UK and France.
But again landmark work being done for CFIDS that could be contributions to clinical diagnosis and care of Gulf War Veterans. Again the need for the VA to set up INTEGRATIVE RESEARCH – Clinical Innovations Centers of Excellence in 8 sites geographically for the gulf war Veterans. Which would speed Research into actual clinical practice in diagnosing and treating Gulf War Veterans.
WE could also ask researchers to include gulf war veterans that have Chronic Fatigue to be included in the sample groups as the studies are approved and therefore also provide a service to Gulf War Veterans. By doing this and having it as a special subgroup identified as such to identify if they are typical or atypical in the research findings. I know many UK veterans who would be glad to have that opportunity.
The two major complaints of gulf war veterans were changes in their physical abilities ie their ability to exercise and endurance. The second was changes in Neurocognitive functioning! The third was IBS. The fourth was MCS.
An expert that should also be serving as a consultant for the VA would be DR Martin Pall from the University of Washington. Dr Myhill’s work on an ATP Profile should be investigated quickly on a small group of gulf war veterans to ascern if there is a connection to the ALS and MS that is becoming very prevalent in gulf war veterans.
1. Int J Clin Exp Med. 2009;2(1):1-16. Epub 2009 Jan 15. Links
Chronic fatigue syndrome and mitochondrial dysfunction.Myhill S, Booth NE, McLaren-Howard J.
This study aims to improve the health of patients suffering from chronic fatigue syndrome (CFS) by interventions based on the biochemistry of the illness, specifically the function of mitochondria in producing ATP (adenosine triphosphate), the energy currency for all body functions, and recycling ADP (adenosine diphosphate) to replenish the ATP supply as needed.
Patients attending a private medical practice specializing in CFS were diagnosed using the Centers for Disease Control criteria.
In consultation with each patient, an integer on the Bell Ability Scale was assigned, and a blood sample was taken for the "ATP profile" test, designed for CFS and other fatigue conditions. Each test produced 5 numerical factors which describe the availability of ATP in neutrophils, the fraction complexed with magnesium, the efficiency of oxidative phosphorylation, and the transfer efficiencies of ADP into the mitochondria and ATP into the cytosol where the energy is used.
With the consent of each of 71 patients and 53 normal, healthy controls the 5 factors have been collated and compared with the Bell Ability Scale. The individual numerical factors show that patients have different combinations of biochemical lesions. When the factors are combined, a remarkable correlation is observed between the degree of mitochondrial dysfunction and the severity of illness (P<0.001). Only 1 of the 71 patients overlaps the normal region.
2. J Intern Med. 2009 May 19. [Epub ahead of print] Links
Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses.Jammes Y, Steinberg JG, Delliaux S, Brégeon F.
From the UMR MD2 (P2COE); and IFR Jean Roche, Faculté de Médecine, Université de la Méditerranée and Pulmonary Function Laboratory, North Hospital, Assistance Publique – Hôpitaux de Marseille, France.
Abstract. Jammes Y, Steinberg JG, Delliaux S, Brégeon F (Université de la Méditerranée and Pulmonary Function Laboratory, North Hospital, Assistance Publique – Hôpitaux de Marseille, France). Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. J Intern Med 2009; doi: 10.1111/j.1365-2796.2009.02079.x
Objectives. As heat shock proteins (Hsp) protect the cells against the deleterious effects of oxidative stress, we hypothesized that Hsp expression might be reduced in patients suffering from chronic fatigue syndrome (CFS) who present an accentuated exercise-induced oxidative stress.
Design. This case-control study compared nine CFS patients to a gender-, age- and weight-matched control group of nine healthy sedentary subjects.
Interventions. All subjects performed an incremental cycling exercise continued until exhaustion. We measured ventilation and respiratory gas exchange and evoked compound muscle potential (M-wave) recorded from vastus lateralis. Repetitive venous blood sampling allowed measurements of two markers of oxidative stress [thiobarbituric acid reactive substances (TBARS) and reduced ascorbic acid (RAA)], two cytokines (IL-6 and TNF-alpha) and two Hsp (Hsp27 and Hsp70) at rest, during maximal exercise and the 60-min recovery period.
Results. Compared with controls, resting CFS patients had low baseline levels of RAA and Hsp70. Their response to maximal exercise associated (i) M-wave alterations indicating reduced muscle membrane excitability, (ii) early and accentuated TBARS increase accompanying reduced changes in RAA level, (iii) absence of significant increase in IL-6 and TNF-alpha, and (iv) delayed and marked reduction of Hsp27 and Hsp70 variations. The post-exercise increase in TBARS was accentuated in individuals having the lowest variations of Hsp27 and Hsp70.
Conclusions. The response of CFS patients to incremental exercise associates a lengthened and accentuated oxidative stress, which might result from delayed and insufficient Hsp production.
PMID: 19457057 [PubMed – as supplied by publisher]
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